名称：抗LONP1抗体(anti- LONP1 antibody)

　　货号：FNab04821

　　适应种属：人源，小鼠，大鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：蛋白A/G柱纯化

　　纯度：经sds-page分析,纯度大于95

　　宿主：小鼠

　　亚型：IgG2a

　　存储：用添加了0.02叠氮化钠和50甘油的pbs溶解,ph值7.3,可在-20℃下保存12个月（避免反复冻融）

　　免疫原：lon peptidase 1, mitochondrial

　　免疫原别称：PRSS15

　　分子量：100 kDa

　　验证应用：ELISA, WB, IHC, IF

　　建议稀释比例：WB: 1:500-1:10000; IHC: 1:400-1:1600; IF: 1:10-1:100

　　克隆性：单克隆

　　uniprot id：P36776

　　背景介绍：ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein。

　　图像：

　　Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab04821 (LONP1 Antibody) at dilution of 1:800 heat mediated antigen retrieved with Tris-EDTA buffer (pH9)。

　　Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04821 (LONP1 Antibody) at dilution of 1:5000。